Gene duplication and the evolution of moonlighting proteins
نویسندگان
چکیده
منابع مشابه
Gene duplication and the evolution of moonlighting proteins
Gene duplication is a recurring phenomenon in genome evolution and a major driving force in the gain of biological functions. Here, we examine the role of gene duplication in the origin and maintenance of moonlighting proteins, with special focus on functional redundancy and innovation, molecular tradeoffs, and genetic robustness. An overview of specific examples-mainly from yeast-suggests a wi...
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15 صفحه اولGene duplication and evolution.
Lynch and Conery (1) presented one of the first serious efforts to study the evolutionary fate of gene duplication using genomic sequence data. Their analysis led to several interesting observations, particularly with respect to the rate of gene duplication in eukaryotic genomes and the subsequent halflife of duplicates. These two parameters are of particular importance in studying the evolutio...
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Multitasking or moonlighting is the capability of some proteins to execute two or more biochemical functions. Usually, moonlighting proteins are experimentally revealed by serendipity. For this reason, it would be helpful that Bioinformatics could predict this multifunctionality, especially because of the large amounts of sequences from genome projects. In the present work, we analyze and descr...
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Moonlighting proteins, characterized by their multiple autonomous functions, have been detected in bacteria. Surprisingly, many of these proteins are conserved and involved in metabolic pathway or the cell stress response. They localise to the bacterial surface to take on additional activities, which have been hypothesised to contribute to bacterial virulence or bacterial benefit. In this revie...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2015
ISSN: 1664-8021
DOI: 10.3389/fgene.2015.00227